Management of Thalassemia

talesemler
Management of thalassemia depends on the severity of disease. No management is needed for thalassemia carriers. We refer people to genetic counseling and diagnosis centers in order to ensure they have healthy children. In thalassemia intermedia, i.e. intermediate thalassemia, people are transfused blood whenever they need. For patients with increased iron load, iron-lowering therapy – chelation- is started. In most severe cases, also referred as thalassemia major, patients are required to be transfused blood at monthly intervals to survive. Relevant management should be started to decrease iron lead after 2 years of age.

Repeated blood transfusions result in iron depositions in vital organs such as heart and liver, resulting with life-threatening side effects, including but not limited to heart failure and cirrhosis, at adolescence. However, definitive management is the bone marrow transplantation. If the patient has a haploidentic sibling, the disease can be completely cured with bone marrow transplantation, and the patient will be free from blood transfusions, and subsequently, excessive iron deposition is eliminated.

  • We refer people to genetic counseling and diagnosis centers in order to ensure they have healthy children

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